CRBN and PRKAG1

Number of citations of the paper that reports this interaction (PubMedID 32333926)
0

Data Source:
BioGRID (enzymatic study)

		CRBN	PRKAG1
Description		cereblon	protein kinase AMP-activated non-catalytic subunit gamma 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle
Pathways		Potential therapeutics for SARS	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Lenalidomide Thalidomide Pomalidomide	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)	Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2	31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC TEKT1 TNFAIP1
Entrez ID		51185	5571
HPRD ID		16750	04118
Ensembl ID		ENSG00000113851	ENSG00000181929
Uniprot IDs		Q96SW2	F8VYY9 P54619
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels	Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process
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