CRBN and CYP19A1

Number of citations of the paper that reports this interaction (PubMedID 32219443)
0

Data Source:
BioGRID (pull down)

		CRBN	CYP19A1
Description		cereblon	cytochrome P450 family 19 subfamily A member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Aromatase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development	Negative Regulation Of Chronic Inflammatory Response Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process Syncytium Formation Androgen Metabolic Process Female Gonad Development Negative Regulation Of Macrophage Chemotaxis Sterol Metabolic Process Female Genitalia Development Mammary Gland Development Response To Estradiol Uterus Development Prostate Gland Growth Testosterone Biosynthetic Process Positive Regulation Of Estradiol Secretion
Pathways		Potential therapeutics for SARS	Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes AEXS
Drugs		Lenalidomide Thalidomide Pomalidomide	Nicotine Aminoglutethimide Estrone Testolactone Exemestane Letrozole Anastrozole 2-Methoxyestradiol Naringenin Glyphosate MPI-674 Mitapivat
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)	Aromatase excess syndrome 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)	Airway wall thickness ( 25517131) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 31757997) Cerebrospinal fluid AB1-42 levels ( 20932310) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Estradiol levels ( 34255042 22675492 29325096) Estrone levels ( 29325096) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Follicle stimulating hormone levels ( 24049095) Heel bone mineral density ( 28869591 30598549) Height ( 23456168 20881960 33713608 31562340 20189936 25429064 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hormone measurements ( 24049095) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Menarche (age at onset) ( 23599027) Neutrophil percentage of white cells ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301 29403010) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2	2 interacting genes: CRBN FANCG
Entrez ID		51185	1588
HPRD ID		16750	00488
Ensembl ID		ENSG00000113851	ENSG00000137869
Uniprot IDs		Q96SW2	A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO	3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 5JKV 5JKW 5JL6 5JL7 5JL9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels
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