CRBN and OSR1

Number of citations of the paper that reports this interaction (PubMedID 30385546)
43

Data Source:
BioGRID (pull down)

		CRBN	OSR1
Description		cereblon	odd-skipped related transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Cytosol Cell Cortex
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding Transporter Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Ureteric Bud Development Mesonephros Development Chondrocyte Differentiation Pattern Specification Process Heart Development Gonad Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Negative Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transmembrane Transport Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Sodium Ion Transmembrane Transport Embryonic Skeletal Limb Joint Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Intermediate Mesoderm Development Pronephros Development Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Retinoic Acid Metanephric Mesenchyme Development Cell Proliferation Involved In Kidney Development Metanephric Mesenchyme Morphogenesis Mesangial Cell Development Metanephric Mesenchymal Cell Differentiation Posterior Mesonephric Tubule Development Specification Of Anterior Mesonephric Tubule Identity Specification Of Posterior Mesonephric Tubule Identity Mesonephric Duct Morphogenesis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Renal Vesicle Progenitor Cell Differentiation Ureter Urothelium Development Metanephric Epithelium Development Metanephric Smooth Muscle Tissue Development Metanephric Nephron Tubule Development Metanephric Glomerulus Vasculature Development Metanephric Interstitial Fibroblast Development Pattern Specification Involved In Metanephros Development Embryonic Skeletal Joint Development Metanephric Cap Mesenchymal Cell Proliferation Involved In Metanephros Development Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Gastrulation
Pathways		Potential therapeutics for SARS	Formation of intermediate mesoderm Formation of the nephric duct
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)	Childhood ear infection ( 27182965 28928442) Coronary artery disease ( 32469254 33020668) Facial morphology ( 29921221) Monobrow ( 27182965) Pulse pressure ( 26390057 27841878 28739976) Systolic blood pressure ( 27841878)
Interacting Genes		47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2	3 interacting genes: CRBN TGFBR1 TGFBR2
Entrez ID		51185	130497
HPRD ID		16750	16401
Ensembl ID		ENSG00000113851	ENSG00000143867
Uniprot IDs		Q96SW2	Q8TAX0
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels	Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Ligand-receptor Complex Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Binding Response To Cholesterol Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lens Development In Camera-type Eye SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Artery Morphogenesis Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Roof Of Mouth Development Embryonic Skeletal System Morphogenesis Epithelial To Mesenchymal Transition Regulation Of Stem Cell Proliferation Blood Vessel Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Embryonic Organ Morphogenesis Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Positive Regulation Of Vasculature Development Bronchus Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type II Positive Regulation Of B Cell Tolerance Induction Mammary Gland Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Receptor Complex Membrane Raft Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Growth Plate Cartilage Chondrocyte Growth
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