CRBN

Gene Name		cereblon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	ATP-dependent Peptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein Homooligomerization Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homodimerization Activity
Pathways
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22542470) White matter integrity ( 23218918)
Protein-protein Interactions		5 interactors: KDM1A MEIS2 PAK7 RBPMS SUV39H1
Entrez ID		51185
HPRD ID		16750
Ensembl ID		ENSG00000113851
Uniprot IDs		Q96SW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Histone H3-K9 Dimethylation RNA Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Positive Regulation Of Megakaryocyte Differentiation Histone H3-K9 Trimethylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Peptidyl-lysine Dimethylation Macromolecule Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Silencing At RDNA Granulocyte Differentiation Regulation Of SMAD Protein Import Into Nucleus Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Circadian Rhythm Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of RNA Metabolic Process Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-lysine Trimethylation Nucleobase-containing Compound Metabolic Process
Tagcloud ?		activates amp ampk binds cereblon controlling delayed deletion dephosphorylation desensitized eif2alpha embryonic endoplasmic fibroblast implying inducers lastly mechanistically perk pkr promoting propose reconstitution regulates reticulum reversed stimuli stress unfolded