NAGPA and BDKRB1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NAGPA	BDKRB1
Description		N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	bradykinin receptor B1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane Golgi Cisterna Membrane	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding Hydrolase Activity	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes Protein Modification Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		N-Acetylglucosamine	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)	Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		51172	623
HPRD ID		12145	02639
Ensembl ID		ENSG00000103174	ENSG00000100739
Uniprot IDs		Q9UK23	P46663
PDB IDs			7EIB
Enriched GO Terms of Interacting Partners?		Postsynaptic Endocytic Zone Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Golgi To Endosome Transport Peptide Binding Receptor Internalization Clathrin-coated Vesicle Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Sphingolipid Delta-4 Desaturase Activity Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Bradykinin Receptor Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Retinol Isomerase Activity Symbiont Entry Into Host Cell Cytosolic Transport Negative Regulation Of Receptor Catabolic Process Regulation Of Biological Quality Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Translation Viral Life Cycle Plasma Membrane Biological Process Involved In Interaction With Host Cytokine Precursor Processing Nerve Growth Factor Binding Receptor-mediated Endocytosis Ubiquitin-dependent Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Heparan Sulfate Binding Signal Peptide Processing Retinal Bipolar Neuron Differentiation Clathrin Adaptor Complex Receptor-mediated Endocytosis Of Virus By Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Golgi Vesicle Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding
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