NAGPA and DEGS1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NAGPA	DEGS1
Name		N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	delta 4-desaturase, sphingolipid 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane Golgi Cisterna Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Membrane
	Molecular Function	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding Hydrolase Activity	Protein Binding Electron Transfer Activity Oxidoreductase Activity Isomerase Activity Sphingolipid Delta-4 Desaturase Activity Retinol Isomerase Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes Protein Modification Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Biosynthetic Process Myelin Maintenance Ceramide Biosynthetic Process
Pathways		None	Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs		N-Acetylglucosamine	None
GWAS		Blood protein levels ( 30072576 )	Red blood cell count ( 32888494 )
Interacting Genes		7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2	4 interacting genes: CFTR EGFR NAGPA SEMA4G
Entrez ID		51172	8560
HPRD ID		12145	13133
Ensembl ID		ENSG00000103174	ENSG00000143753
Uniprot IDs		Q9UK23	O15121
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynaptic Endocytic Zone Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Golgi To Endosome Transport Peptide Binding Receptor Internalization Clathrin-coated Vesicle Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Sphingolipid Delta-4 Desaturase Activity Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Bradykinin Receptor Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Retinol Isomerase Activity Symbiont Entry Into Host Cell Cytosolic Transport Negative Regulation Of Receptor Catabolic Process Regulation Of Biological Quality Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Translation Viral Life Cycle Plasma Membrane Biological Process Involved In Interaction With Host Cytokine Precursor Processing Nerve Growth Factor Binding Receptor-mediated Endocytosis Ubiquitin-dependent Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Heparan Sulfate Binding Signal Peptide Processing Retinal Bipolar Neuron Differentiation Clathrin Adaptor Complex Receptor-mediated Endocytosis Of Virus By Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Golgi Vesicle Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell	Telencephalon Cell Migration Cerebral Cortex Cell Migration Forebrain Cell Migration Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Positive Regulation Of Wnt Signaling Pathway Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Early Endosome Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling Cell Migration Secretion Of Lysosomal Enzymes Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Basolateral Plasma Membrane Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway Cell Motility Radial Glia-guided Pyramidal Neuron Migration Cerebral Cortex Radial Glia-guided Migration Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Salivary Gland Morphogenesis Ciliary Basal Body Regulation Of Wnt Signaling Pathway Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Response To UV-A Negative Regulation Of Cardiocyte Differentiation Golgi-associated Vesicle Membrane Eyelid Development In Camera-type Eye