NAGPA and CCR8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NAGPA	CCR8
Description		N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	C-C motif chemokine receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane Golgi Cisterna Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding Hydrolase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes Protein Modification Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		N-Acetylglucosamine
Diseases
GWAS		Blood protein levels ( 30072576)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		51172	1237
HPRD ID		12145	03497
Ensembl ID		ENSG00000103174	ENSG00000179934
Uniprot IDs		Q9UK23	P51685
PDB IDs			8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
Enriched GO Terms of Interacting Partners?		Postsynaptic Endocytic Zone Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Golgi To Endosome Transport Peptide Binding Receptor Internalization Clathrin-coated Vesicle Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Sphingolipid Delta-4 Desaturase Activity Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Bradykinin Receptor Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Retinol Isomerase Activity Symbiont Entry Into Host Cell Cytosolic Transport Negative Regulation Of Receptor Catabolic Process Regulation Of Biological Quality Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Translation Viral Life Cycle Plasma Membrane Biological Process Involved In Interaction With Host Cytokine Precursor Processing Nerve Growth Factor Binding Receptor-mediated Endocytosis Ubiquitin-dependent Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Heparan Sulfate Binding Signal Peptide Processing Retinal Bipolar Neuron Differentiation Clathrin Adaptor Complex Receptor-mediated Endocytosis Of Virus By Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Golgi Vesicle Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex
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