NAGPA and ZHX2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NAGPA	ZHX2
Name		N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	zinc fingers and homeoboxes 2
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane Golgi Cisterna Membrane	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding Hydrolase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes Protein Modification Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Nervous System Development Central Nervous System Neuron Differentiation Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Retinal Bipolar Neuron Differentiation
Drugs		N-Acetylglucosamine	None
GWAS		Blood protein levels ( 30072576 )	Appendicular lean mass ( 33097823 ) Carotid intima media thickness ( 21909108 30510157 ) Chin dimples ( 27182965 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Reticulocyte count ( 32888494 )
Interacting Genes		7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2	9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3
Entrez ID		51172	22882
HPRD ID		12145	16458
Ensembl ID		ENSG00000103174	ENSG00000178764
Uniprot IDs		Q9UK23	Q9Y6X8
PDB IDs		Not available	2DMP 3NAU
GO Terms Enriched among Interactors		Postsynaptic Endocytic Zone Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Golgi To Endosome Transport Peptide Binding Receptor Internalization Clathrin-coated Vesicle Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Sphingolipid Delta-4 Desaturase Activity Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Bradykinin Receptor Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Retinol Isomerase Activity Symbiont Entry Into Host Cell Cytosolic Transport Negative Regulation Of Receptor Catabolic Process Regulation Of Biological Quality Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Translation Viral Life Cycle Plasma Membrane Biological Process Involved In Interaction With Host Cytokine Precursor Processing Nerve Growth Factor Binding Receptor-mediated Endocytosis Ubiquitin-dependent Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Heparan Sulfate Binding Signal Peptide Processing Retinal Bipolar Neuron Differentiation Clathrin Adaptor Complex Receptor-mediated Endocytosis Of Virus By Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Golgi Vesicle Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Adult Locomotory Behavior Negative Regulation Of RNA Biosynthetic Process Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Localization Protein Heterodimerization Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Localization To Lysosome Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Establishment Of Protein Localization To Vacuole Protein Targeting Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Protein Targeting To Lysosome Protein Targeting To Vacuole Synaptic Vesicle Recycling Via Endosome TCR Signalosome N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Vacuole Lipophagy Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding