EHHADH and CYB561A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EHHADH	CYB561A3
Description		enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	cytochrome b561 family member A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol	Nucleolus Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane
	Molecular Function	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding	Protein Binding Oxidoreductase Activity Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process	Intracellular Iron Ion Homeostasis Transmembrane Transport
Pathways		Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs		NADH
Diseases
GWAS		Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17	23 interacting genes: AGPAT5 AOC1 AQP6 CD40 CD79A CLDN5 CLDN7 CREB3L3 EHHADH FFAR2 GPR101 GPR152 GPR37L1 GPX8 HERPUD2 KLRC1 LAPTM4B PVR RNF185 RNF5 SHISAL1 TM4SF18 TMEM31
Entrez ID		1962	220002
HPRD ID		06125	11316
Ensembl ID		ENSG00000113790	ENSG00000162144
Uniprot IDs		Q08426	F5H1Q2 Q8NBI2
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport	Membrane Ubiquitin-like Protein Conjugating Enzyme Binding Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Apicolateral Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Alpha-1,2-demannosylation Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Mannose Trimming Endoplasmic Reticulum Quality Control Compartment Protein Deglycosylation Bicellular Tight Junction Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Nitrate Transmembrane Transporter Activity Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Inhibitory MHC Class Ib Receptor Activity B Cell Proliferation G Protein-coupled Receptor Activity Plasma Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Activation Of Immune Response Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Innate Immune Response-activating Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Acute Inflammatory Response HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Receptor Complex Regulation Of T Cell Mediated Cytotoxicity
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