EHHADH and CAT

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (proximity labelling technology, cross-linking study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		EHHADH	CAT
Description		enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	catalase
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Catalase Complex Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding	Aminoacylase Activity Catalase Activity Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Kidney Development Triglyceride Metabolic Process Response To Oxidative Stress Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To UV Response To Toxic Substance Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Response To Activity Response To Inactivity Hemoglobin Metabolic Process Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hyperoxia Cellular Detoxification Of Hydrogen Peroxide Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Amitrole Response To Phenylpropanoid
Pathways		Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs		NADH	Fomepizole Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases			Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)	Blood protein levels ( 30072576)
Interacting Genes		98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17	9 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 OGT PTPN11 SUMO4 TLR10
Entrez ID		1962	847
HPRD ID		06125	00282
Ensembl ID		ENSG00000113790	ENSG00000121691
Uniprot IDs		Q08426	A0A384P5Q0 P04040
PDB IDs			1DGB 1DGF 1DGG 1DGH 1F4J 1QQW 7P8W 7VD9 8EL9 8HID 8PVD 8SGV 8WZH 8WZJ 8WZK 8WZM
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport	Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Response To Stress Positive Regulation Of T Cell Migration Enzyme Binding Phosphotyrosine Residue Binding Protein-containing Complex Positive Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of T Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Migration ERBB Signaling Pathway Enzyme Activator Activity Bergmann Glial Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Positive Regulation Of Cell-cell Adhesion Cellular Response To Catecholamine Stimulus Positive Regulation Of Mitotic Cell Cycle Response To Catecholamine Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Mononuclear Cell Migration Regulation Of Establishment Of Cell Polarity Insulin Receptor Binding Positive Regulation Of Leukocyte Migration Actin Monomer Binding Cell Activation Involved In Immune Response Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of MAPK Cascade Ephrin Receptor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Hemopoiesis Cellular Response To Stress Astrocyte Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway
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