KMT5B and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 19074285)
38

Data Source:
BioGRID (pull down)

		KMT5B	GRIP1
Description		lysine methyltransferase 5B	glutamate receptor interacting protein 1
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GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Plasma Membrane Cilium Microtubule Cytoskeleton Ciliary Basal Body Cytoplasmic Ribonucleoprotein Granule Intercellular Bridge Mitotic Spindle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling Muscle Organ Development Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
Pathways		PKMTs methylate histone lysines	Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases
GWAS		Urate levels ( 31578528)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		7 interacting genes: ESR1 GRIP1 H4C1 H4C2 H4C7 SMARCD1 TSPYL2	46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		51111	23426
HPRD ID		11616	19086
Ensembl ID		ENSG00000110066	ENSG00000155974
Uniprot IDs		A0A8V8TQB9 B5MCB3 B7WNX0 B7Z5N2 C9J6S5 C9JFG1 Q4FZB7	A0A8V8TLS6 Q9Y3R0
PDB IDs		3S8P 5CPR 5WBV 7YRD 7YRG 8JHF 8JHG 8T68 8T9F 8T9H	2JIL
Enriched GO Terms of Interacting Partners?		Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Localization To Chromatin Protein-containing Complex Organization Structural Constituent Of Chromatin Protein Localization To Chromosome Nucleosome CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein-containing Complex Assembly Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Heterodimerization Activity Regulation Of Hemopoiesis Negative Regulation Of Myeloid Cell Differentiation Chromatin Binding Beta-catenin Binding Cellular Component Assembly Regulation Of Developmental Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Telomere Organization Nuclear Estrogen Receptor Activity Protein Localization To Organelle TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Regulation Of Immune System Process Negative Regulation Of Cell Differentiation Chromosome Chromosome, Telomeric Region Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Protein-containing Complex Regulation Of Nitric-oxide Synthase Activity RDNA Binding Intracellular Protein Localization Nitric-oxide Synthase Regulator Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Neuron Projection Arborization Regulation Of Cell Development Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Prostate Gland Growth Vagina Development	Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding
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