KMT5B and H4C7

Number of citations of the paper that reports this interaction (PubMedID 35907431)
0

Data Source:
BioGRID (enzymatic study)

		KMT5B	H4C7
Description		lysine methyltransferase 5B	H4 clustered histone 7
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Plasma Membrane Cilium Microtubule Cytoskeleton Ciliary Basal Body Cytoplasmic Ribonucleoprotein Granule Intercellular Bridge Mitotic Spindle	Nucleosome Nucleus Chromosome
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling Muscle Organ Development Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		7 interacting genes: ESR1 GRIP1 H4C1 H4C2 H4C7 SMARCD1 TSPYL2	13 interacting genes: AGTRAP APOC1 CIDEB EP300 FGF14 FKBP7 KAT2A KAT8 KMT5B KMT5C MAIP1 RHBDD2 TMED8
Entrez ID		51111	8369
HPRD ID		11616	11806
Ensembl ID		ENSG00000110066	ENSG00000275663
Uniprot IDs		A0A8V8TQB9 B5MCB3 B7WNX0 B7Z5N2 C9J6S5 C9JFG1 Q4FZB7	Q99525
PDB IDs		3S8P 5CPR 5WBV 7YRD 7YRG 8JHF 8JHG 8T68 8T9F 8T9H
Enriched GO Terms of Interacting Partners?		Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Localization To Chromatin Protein-containing Complex Organization Structural Constituent Of Chromatin Protein Localization To Chromosome Nucleosome CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein-containing Complex Assembly Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Heterodimerization Activity Regulation Of Hemopoiesis Negative Regulation Of Myeloid Cell Differentiation Chromatin Binding Beta-catenin Binding Cellular Component Assembly Regulation Of Developmental Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Telomere Organization Nuclear Estrogen Receptor Activity Protein Localization To Organelle TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Regulation Of Immune System Process Negative Regulation Of Cell Differentiation Chromosome Chromosome, Telomeric Region Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Protein-containing Complex Regulation Of Nitric-oxide Synthase Activity RDNA Binding Intracellular Protein Localization Nitric-oxide Synthase Regulator Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Neuron Projection Arborization Regulation Of Cell Development Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Prostate Gland Growth Vagina Development	Histone Acetyltransferase Complex Protein Propionyltransferase Activity Protein-lysine-acetyltransferase Activity Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone Acetyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Very-low-density Lipoprotein Particle Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Condensed Chromosome, Centromeric Region Negative Regulation Of Gluconeogenesis Chromosome Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains S-adenosyl-L-methionine Binding Positive Regulation Of Adaptive Immune Response Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Acyltransferase Activity Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Protein Acetylation DNA-binding Transcription Factor Binding Chromatin Binding Regulation Of Isotype Switching Regulation Of Triglyceride Metabolic Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Somitogenesis Peptidyl-lysine Propionylation Segmentation Regulation Of Lymphocyte Activation Swimming Histone Lactyltransferase (CoA-dependent) Activity Gluconeogenesis Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity
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