KMT5B and TSPYL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KMT5B	TSPYL2
Description		lysine methyltransferase 5B	TSPY like 2
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Plasma Membrane Cilium Microtubule Cytoskeleton Ciliary Basal Body Cytoplasmic Ribonucleoprotein Granule Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling Muscle Organ Development Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Nucleosome Assembly Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		PKMTs methylate histone lysines	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		7 interacting genes: ESR1 GRIP1 H4C1 H4C2 H4C7 SMARCD1 TSPYL2	51 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 DYRK1A EEF1A1 EZH2 GFI1B H2BC15 H3C1 HMGXB4 INO80B KDM6A KDM6B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B YAP1 ZBTB24 ZBTB48 ZFP1 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		51111	64061
HPRD ID		11616	06713
Ensembl ID		ENSG00000110066	ENSG00000184205
Uniprot IDs		A0A8V8TQB9 B5MCB3 B7WNX0 B7Z5N2 C9J6S5 C9JFG1 Q4FZB7	Q9H2G4
PDB IDs		3S8P 5CPR 5WBV 7YRD 7YRG 8JHF 8JHG 8T68 8T9F 8T9H
Enriched GO Terms of Interacting Partners?		Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Localization To Chromatin Protein-containing Complex Organization Structural Constituent Of Chromatin Protein Localization To Chromosome Nucleosome CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein-containing Complex Assembly Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Heterodimerization Activity Regulation Of Hemopoiesis Negative Regulation Of Myeloid Cell Differentiation Chromatin Binding Beta-catenin Binding Cellular Component Assembly Regulation Of Developmental Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Telomere Organization Nuclear Estrogen Receptor Activity Protein Localization To Organelle TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Regulation Of Immune System Process Negative Regulation Of Cell Differentiation Chromosome Chromosome, Telomeric Region Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Protein-containing Complex Regulation Of Nitric-oxide Synthase Activity RDNA Binding Intracellular Protein Localization Nitric-oxide Synthase Regulator Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Neuron Projection Arborization Regulation Of Cell Development Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Prostate Gland Growth Vagina Development	Nucleus Chromatin Organization Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Nucleolus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Repair RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA Metabolic Process Chromatin Binding Zinc Ion Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin DNA Binding Transcription Regulator Complex Cyclin B1-CDK1 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Metal Ion Binding Cellular Response To Stress Telomere Organization Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3K27me2/H3K27me3 Demethylase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA Repair Protein Localization To Site Of Double-strand Break Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cardiac Muscle Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Activity
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