SUV420H1

Gene Name		suppressor of variegation 4-20 homolog 1 (Drosophila)
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Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region
	Molecular Function	Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific)
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Histone H4-K20 Trimethylation
Pathways
Drugs
Diseases
GWAS		IgG glycosylation ( 23382691)
Protein-protein Interactions		3 interactors: ESR1 HIST1H4A SMARCD1
Entrez ID		51111
HPRD ID		11616
Ensembl ID		ENSG00000110066
Uniprot IDs		B5MCB3 Q4FZB7
PDB IDs		3S8P
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Modification Chromatin Organization Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Regulation Of Gene Expression, Epigenetic Histone H4-K20 Demethylation Prostate Epithelial Cord Elongation Negative Regulation Of Megakaryocyte Differentiation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Chromatin-mediated Maintenance Of Transcription Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis DNA Methylation On Cytosine Vagina Development Nucleosome Disassembly Uterus Development Chromatin Silencing At RDNA Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Megakaryocyte Differentiation Cellular Response To Estradiol Stimulus Prostate Gland Growth Organelle Organization Branching Involved In Prostate Gland Morphogenesis Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium CENP-A Containing Nucleosome Assembly Cellular Response To Estrogen Stimulus Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Chromatin Silencing DNA Replication-independent Nucleosome Assembly Axis Elongation Histone Lysine Demethylation Histone Demethylation Protein Demethylation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity
Tagcloud ?		aspects breast cancerous clearly clinicopathological ectopic elucidate global goal h3k9me3 h4 h4k20 h4k20me3 importantly independently invasion invasiveness knockdown luminal lysine mammary methyltransferases modification mostly multivariate pathological trimethylation univariate