LACTB2 and NAGK

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		LACTB2	NAGK
Name		lactamase beta 2	N-acetylglucosamine kinase
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Single-stranded RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity
	Biological Process	None	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination
Pathways		None	Synthesis of UDP-N-acetyl-glucosamine
Drugs		None	N-Acetylglucosamine
GWAS		Diverticular disease ( 30177863 ) Erythrocyte cadmium concentration in never smokers ( 27005419 )	Blood protein levels ( 30072576 ) Erythema nodosum in inflammatory bowel disease ( 24487271 )
Novel Interactors		None recorded	1 novel interactors: ELP4
Interacting Genes		2 interacting genes: NAGK SIAH1	36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82
Entrez ID		51110	55577
HPRD ID		13955	08441
Ensembl ID		ENSG00000147592	ENSG00000124357
Uniprot IDs		A0A024R811 Q53H82	A0A384N6G7 C9JEV6 Q9UJ70
PDB IDs		4AD9	2CH5 2CH6
GO Terms Enriched among Interactors		N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Muramyl Dipeptide Kinase Activity Beta-catenin Destruction Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination UDP-N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Protein Linear Polyubiquitination Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylglucosamine Catabolic Process N-acetylneuraminate Metabolic Process N-acetylneuraminate Catabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway N-acetylglucosamine Metabolic Process Post-translational Protein Modification Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Carbohydrate Phosphorylation Response To Muramyl Dipeptide P38MAPK Cascade Nucleotide-sugar Biosynthetic Process Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Intracellular Signal Transduction Amino Sugar Metabolic Process Nucleotide-sugar Metabolic Process Protein Destabilization Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein Modification Process Transferase Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway	Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process