NOSIP and KPNA1

Number of citations of the paper that reports this interaction (PubMedID 36690276)
66

Data Source:
BioGRID (pull down)

		NOSIP	KPNA1
Description		nitric oxide synthase interacting protein	karyopherin subunit alpha 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Catalytic Activity Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway
Pathways		NOSIP mediated eNOS trafficking	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		13 interacting genes: CEBPA IPO13 IPO5 IPO7 KPNA1 KPNB1 NOS1 NOS3 PPP2CA UBC UBE2D3 XPO1 ZNF410	49 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5
Entrez ID		51070	3836
HPRD ID		17642	02819
Ensembl ID		ENSG00000142546	ENSG00000114030
Uniprot IDs		A0A075B6F9 Q9Y314	P52294
PDB IDs		8C6J 9FMD	2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Establishment Of Localization In Cell Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nucleus NLS-bearing Protein Import Into Nucleus Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Small GTPase Binding Ribosomal Protein Import Into Nucleus Cadmium Ion Binding Protein Transport L-arginine Catabolic Process Intracellular Transport Arginine Binding Nuclear Envelope Establishment Of Protein Localization NLS-dependent Protein Nuclear Import Complex Nuclear Membrane FMN Binding Cellular Localization Arginine Metabolic Process Regulation Of Cell Cycle Nitric Oxide Mediated Signal Transduction Nitric Oxide Biosynthetic Process Nucleoplasm Regulation Of The Force Of Heart Contraction Intracellular Protein Localization RNA Transport Nitric Oxide Metabolic Process Negative Regulation Of Potassium Ion Transport Reactive Nitrogen Species Metabolic Process NADP Binding Hsp90 Protein Binding Blood Circulation Cell Redox Homeostasis Regulation Of Protein Localization Response To Fluid Shear Stress Nucleobase-containing Compound Transport Regulation Of Hippo Signaling Mitotic Metaphase Chromosome Alignment Negative Regulation Of Blood Pressure	Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination
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