NOSIP and XPO1

Number of citations of the paper that reports this interaction (PubMedID 36690276)
66

Data Source:
BioGRID (pull down)

		NOSIP	XPO1
Description		nitric oxide synthase interacting protein	exportin 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Catalytic Activity Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt
Pathways		NOSIP mediated eNOS trafficking	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Selinexor
Diseases
GWAS		Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CEBPA IPO13 IPO5 IPO7 KPNA1 KPNB1 NOS1 NOS3 PPP2CA UBC UBE2D3 XPO1 ZNF410	86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		51070	7514
HPRD ID		17642	03975
Ensembl ID		ENSG00000142546	ENSG00000082898
Uniprot IDs		A0A075B6F9 Q9Y314	A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980
PDB IDs		8C6J 9FMD	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Establishment Of Localization In Cell Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nucleus NLS-bearing Protein Import Into Nucleus Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Small GTPase Binding Ribosomal Protein Import Into Nucleus Cadmium Ion Binding Protein Transport L-arginine Catabolic Process Intracellular Transport Arginine Binding Nuclear Envelope Establishment Of Protein Localization NLS-dependent Protein Nuclear Import Complex Nuclear Membrane FMN Binding Cellular Localization Arginine Metabolic Process Regulation Of Cell Cycle Nitric Oxide Mediated Signal Transduction Nitric Oxide Biosynthetic Process Nucleoplasm Regulation Of The Force Of Heart Contraction Intracellular Protein Localization RNA Transport Nitric Oxide Metabolic Process Negative Regulation Of Potassium Ion Transport Reactive Nitrogen Species Metabolic Process NADP Binding Hsp90 Protein Binding Blood Circulation Cell Redox Homeostasis Regulation Of Protein Localization Response To Fluid Shear Stress Nucleobase-containing Compound Transport Regulation Of Hippo Signaling Mitotic Metaphase Chromosome Alignment Negative Regulation Of Blood Pressure	Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription
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