NOSIP and KPNB1

Number of citations of the paper that reports this interaction (PubMedID 36690276)
66

Data Source:
BioGRID (pull down, pull down)

		NOSIP	KPNB1
Description		nitric oxide synthase interacting protein	karyopherin subunit beta 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Protein-containing Complex Specific Granule Lumen NLS-dependent Protein Nuclear Import Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity Molecular Sequestering Activity	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Small GTPase Binding Hsp90 Protein Binding Nuclear Import Signal Receptor Activity Importin-alpha Family Protein Binding
	Biological Process	Negative Regulation Of Catalytic Activity Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	RNA Import Into Nucleus Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Protein Transport Astral Microtubule Organization Positive Regulation Of Hippo Signaling Establishment Of Mitotic Spindle Localization Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Mitotic Spindle Assembly
Pathways		NOSIP mediated eNOS trafficking	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production SARS-CoV-1 activates/modulates innate immune responses Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		13 interacting genes: CEBPA IPO13 IPO5 IPO7 KPNA1 KPNB1 NOS1 NOS3 PPP2CA UBC UBE2D3 XPO1 ZNF410	75 interacting genes: AMFR CCNB1 CCNE1 CD99 CDC25C CEBPA CHD3 CRBN CSE1L CSNK1A1 CUL4B DSCAM ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA6 LBR LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NOSIP NUP153 NUP50 NUP54 NUP62 NUP98 OGT PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP2 RANBP3 RBX1 RNF10 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAI1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5
Entrez ID		51070	3837
HPRD ID		17642	04114
Ensembl ID		ENSG00000142546	ENSG00000108424
Uniprot IDs		A0A075B6F9 Q9Y314	B7Z752 Q14974
PDB IDs		8C6J 9FMD	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89 8GCN
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Establishment Of Localization In Cell Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nucleus NLS-bearing Protein Import Into Nucleus Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Small GTPase Binding Ribosomal Protein Import Into Nucleus Cadmium Ion Binding Protein Transport L-arginine Catabolic Process Intracellular Transport Arginine Binding Nuclear Envelope Establishment Of Protein Localization NLS-dependent Protein Nuclear Import Complex Nuclear Membrane FMN Binding Cellular Localization Arginine Metabolic Process Regulation Of Cell Cycle Nitric Oxide Mediated Signal Transduction Nitric Oxide Biosynthetic Process Nucleoplasm Regulation Of The Force Of Heart Contraction Intracellular Protein Localization RNA Transport Nitric Oxide Metabolic Process Negative Regulation Of Potassium Ion Transport Reactive Nitrogen Species Metabolic Process NADP Binding Hsp90 Protein Binding Blood Circulation Cell Redox Homeostasis Regulation Of Protein Localization Response To Fluid Shear Stress Nucleobase-containing Compound Transport Regulation Of Hippo Signaling Mitotic Metaphase Chromosome Alignment Negative Regulation Of Blood Pressure	Protein Import Into Nucleus Import Into Nucleus Nucleoplasm Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Transport Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process NLS-dependent Protein Nuclear Import Complex Viral Penetration Into Host Nucleus Nuclear Localization Sequence Binding Establishment Of Protein Localization Intracellular Protein Localization NLS-bearing Protein Import Into Nucleus Positive Regulation Of RNA Metabolic Process Nuclear Envelope Intracellular Transport Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Cellular Localization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Transport Nuclear Import Signal Receptor Activity Intracellular Transport Of Virus Regulation Of Macromolecule Metabolic Process Host Cell Cytoplasm Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Nuclear Membrane Protein Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Transport Establishment Of Localization In Cell Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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