PAM16 and FEZ1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAM16	FEZ1
Gene Name		presequence translocase-associated motor 16 homolog (S. cerevisiae)	fasciculation and elongation protein zeta 1 (zygin I)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Presequence Translocase-associated Import Motor Mitochondrial Inner Membrane Presequence Translocase Complex Mitochondrial Matrix Extrinsic Component Of Mitochondrial Inner Membrane Protein Complex	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	Protein Binding	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Matrix Negative Regulation Of ATPase Activity Cellular Protein Metabolic Process	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		9 interactors: ARL6IP1 BLOC1S2 CEP70 DNAJC19 DNMT3B FEZ1 GPM6A MRFAP1 PGRMC1	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		51025	9638
HPRD ID		14798	09212
Ensembl ID		ENSG00000217930	ENSG00000149557
Uniprot IDs		I3L3T0 Q9Y3D7	Q99689
PDB IDs
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Neuron Projection Development Neuron Development Neuron Differentiation Cell Projection Organization Nervous System Development System Development Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis S-adenosylmethioninamine Metabolic Process Mitochondrial Transport Multicellular Organismal Development DNA Methylation On Cytosine Within A CG Sequence Anatomical Structure Development Cell Development C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Methylation-dependent Chromatin Silencing Establishment Of Localization In Cell Developmental Process Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Positive Regulation Of Cell Projection Organization Cell Morphogenesis Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Negative Regulation Of Macroautophagy Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Establishment Of Organelle Localization Positive Regulation Of Neuron Differentiation Cellular Localization Positive Regulation Of Histone H3-K4 Methylation Establishment Of Mitochondrion Localization Protein Complex Localization Negative Regulation Of Histone Methylation Positive Regulation Of Mitochondrial Membrane Permeability Locomotion Axon Guidance Anterograde Synaptic Vesicle Transport Mitochondrion Organization Melanosome Organization Microtubule Nucleation Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Neurogenesis Regulation Of Histone H3-K4 Methylation	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?			atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?			atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?