PAM16 and DNMT3B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PAM16	DNMT3B
Gene Name		presequence translocase-associated motor 16 homolog (S. cerevisiae)	DNA (cytosine-5-)-methyltransferase 3 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Presequence Translocase-associated Import Motor Mitochondrial Inner Membrane Presequence Translocase Complex Mitochondrial Matrix Extrinsic Component Of Mitochondrial Inner Membrane Protein Complex	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Matrix Negative Regulation Of ATPase Activity Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways		Mitochondrial protein import	NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		9 interactors: ARL6IP1 BLOC1S2 CEP70 DNAJC19 DNMT3B FEZ1 GPM6A MRFAP1 PGRMC1	35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18
Entrez ID		51025	1789
HPRD ID		14798	04209
Ensembl ID		ENSG00000217930	ENSG00000088305
Uniprot IDs		I3L3T0 Q9Y3D7	Q9UBC3
PDB IDs			3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Neuron Projection Development Neuron Development Neuron Differentiation Cell Projection Organization Nervous System Development System Development Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis S-adenosylmethioninamine Metabolic Process Mitochondrial Transport Multicellular Organismal Development DNA Methylation On Cytosine Within A CG Sequence Anatomical Structure Development Cell Development C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Methylation-dependent Chromatin Silencing Establishment Of Localization In Cell Developmental Process Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Positive Regulation Of Cell Projection Organization Cell Morphogenesis Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Negative Regulation Of Macroautophagy Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Establishment Of Organelle Localization Positive Regulation Of Neuron Differentiation Cellular Localization Positive Regulation Of Histone H3-K4 Methylation Establishment Of Mitochondrion Localization Protein Complex Localization Negative Regulation Of Histone Methylation Positive Regulation Of Mitochondrial Membrane Permeability Locomotion Axon Guidance Anterograde Synaptic Vesicle Transport Mitochondrion Organization Melanosome Organization Microtubule Nucleation Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Neurogenesis Regulation Of Histone H3-K4 Methylation	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine
Tagcloud ?			cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?			cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?