ADGRL2

Description		adhesion G protein-coupled receptor L2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Excitatory Synapse Assembly
Pathways
Drugs
Diseases
GWAS		Cataracts ( 34127677) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476) Major depressive episode treated with electroconvulsive therapy ( 33483693)
Novel Interacting Genes		1 novel interacting genes: MUC1
Interacting Genes		3 interacting genes: NCK1 SHANK1 SHANK2
Entrez ID		23266
HPRD ID		06116
Ensembl ID		ENSG00000117114
Uniprot IDs		A0A6I8PIV6 A0A6I8PLG0 A0A6I8PTT2 A0A8I5KUX3 O95490
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Receptor Adaptor Activity Vocalization Behavior Signaling Receptor Complex Adaptor Activity Ionotropic Glutamate Receptor Binding Social Behavior Associative Learning SH3 Domain Binding Determination Of Affect Somatostatin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation Dendritic Spine Learning Adult Behavior Structural Constituent Of Postsynaptic Density Regulation Of Signal Transduction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Habituation Sensory Processing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Postsynaptic Membrane Maintenance Of Postsynaptic Density Structure AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Actin Filament Organization Positive Regulation Of Translation In Response To Stress Postsynaptic Density Learning Or Memory Synapse Organization Nonassociative Learning Ankyrin Repeat Binding Negative Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Substrate-dependent Cell Migration, Cell Extension Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation In Response To Stress Cognition Neuron Projection Righting Reflex Maintenance Of Postsynaptic Specialization Structure Olfactory Behavior Negative Regulation Of Cell Communication Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Signaling
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