LPHN2 and SHANK2

Number of citations of the paper that reports this interaction (PMID 10964907)
14

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		LPHN2	SHANK2
Gene Name		latrophilin 2	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	G-protein Coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding	Protein Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway	Synapse Assembly Learning Memory Adult Behavior Social Behavior Exploration Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Vocalization Behavior
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Temperament ( 22832960)	Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		3 interactors: NCK1 SHANK1 SHANK2	15 interactors: ARHGEF7 BAI2 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 LPHN1 LPHN2 SHARPIN SLC9A3 SSTR2
Entrez ID		23266	22941
HPRD ID		06116	04479
Ensembl ID		ENSG00000117114	ENSG00000162105
Uniprot IDs		O95490	C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Vocalization Behavior Social Behavior Memory Learning Determination Of Affect Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Adult Behavior Synapse Organization Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Peptidyl-serine Dephosphorylation Habituation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Sensory Processing Learning Or Memory Cognition Cellular Component Assembly Nonassociative Learning Regulation Of Actin Cytoskeleton Organization Righting Reflex Synapse Maturation Regulation Of Actin Filament-based Process Nervous System Development Olfactory Behavior Single-organism Behavior Substrate-dependent Cell Migration, Cell Extension Regulation Of Cytoplasmic Translation Regulation Of Cytoskeleton Organization Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Dendritic Spine Morphogenesis Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Translational Initiation Signal Complex Assembly Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemosensory Behavior Regulation Of Translation In Response To Stress Long Term Synaptic Depression Neuron Projection Morphogenesis Dendritic Spine Development Regulation Of Signaling Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Reflex Dendritic Spine Organization Cell Morphogenesis Involved In Differentiation	Cell-cell Signaling Signaling Cell Communication Synaptic Transmission Nervous System Development Neuron Projection Morphogenesis Dendritic Spine Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Morphogenesis Focal Adhesion Assembly Neuron Development Cell Morphogenesis Adherens Junction Assembly Lamellipodium Organization Neuron Differentiation Cell-substrate Junction Assembly Cell Projection Organization Endocytosis Regulation Of Cellular Component Organization Regulation Of Axon Extension Negative Regulation Of Membrane Tubulation Post-Golgi Vesicle-mediated Transport Adherens Junction Organization System Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Synaptic Vesicle Transport Neurogenesis Somatostatin Signaling Pathway Regulation Of Cell Size Regulation Of Cell Projection Organization Dendrite Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Development Multicellular Organismal Development Axonogenesis Maintenance Of Apical/basal Cell Polarity Regulation Of Lamellipodium Morphogenesis Regulation Of Axonogenesis Regulation Of Synaptic Plasticity Cellular Component Assembly G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Receptor Localization To Synapse Dendritic Spine Maintenance
Tagcloud ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Difference) ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Intersection) ?