PCBP2 and SRSF3

Number of citations of the paper that reports this interaction (PubMedID 17183366)
57

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PCBP2	SRSF3
Description		poly(rC) binding protein 2	serine and arginine rich splicing factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding LncRNA Binding Promoter-enhancer Loop Anchoring Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus IRES-dependent Viral Translational Initiation Chromatin Looping CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		45 interacting genes: APOBEC3C BARD1 CASK CEBPA CNBP FLNA FOXP1 FTH1 GAR1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL HNRNPR LINC01554 MECOM NKAP OGT PABPC1 PAXIP1 PCBP1 PDIA3 PRPF40A PTBP1 PTBP2 QKI RALYL RBFOX2 RBMX RBPMS SF3B2 SLC7A11 SLU7 SNRPA SRSF3 SRSF7 SUMO2 UBC UTP25 WDR77 WDR83 YBX1 YBX2 YBX3	40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ
Entrez ID		5094	6428
HPRD ID		03129	04530
Ensembl ID		ENSG00000197111	ENSG00000112081
Uniprot IDs		A0A384N6B9 Q15366	B2R6F3 P84103
PDB IDs		2AXY 2JZX 2P2R 2PQU 2PY9	2I2Y 2I38 9ASQ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding MRNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Splicing MRNA Processing RNA Processing Nucleus Regulation Of MRNA Metabolic Process MRNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleoplasm RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex
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