PCBP2 and SLC7A11

Number of citations of the paper that reports this interaction (PubMedID 36147463)
45

Data Source:
BioGRID (unspecified method)

		PCBP2	SLC7A11
Description		poly(rC) binding protein 2	solute carrier family 7 member 11
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Ribonucleoprotein Complex	Plasma Membrane Cell Surface Membrane Brush Border Membrane Microvillus Membrane Cell Projection Apical Part Of Cell Astrocyte Projection
	Molecular Function	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding LncRNA Binding Promoter-enhancer Loop Anchoring Activity	Protein Binding L-amino Acid Transmembrane Transporter Activity Cystine:glutamate Antiporter Activity Transmembrane Transporter Activity L-kynurenine Transmembrane Transporter Activity
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus IRES-dependent Viral Translational Initiation Chromatin Looping CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	Amino Acid Transmembrane Transport Glutathione Metabolic Process Amino Acid Transport Brain Development Visual Learning Response To Toxic Substance L-cystine Transport L-glutamate Transmembrane Transport Ventricular System Development Striatum Development Adult Behavior Regulation Of Neutrophil Apoptotic Process Cellular Response To Stress Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Melanin Biosynthetic Process Lung Alveolus Development Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Regulation Of Protein Transport Response To Redox State Transmembrane Transport Limb Development Platelet Aggregation Intracellular Glutamate Homeostasis L-glutamate Import Across Plasma Membrane Negative Regulation Of Ferroptosis Dipeptide Import Across Plasma Membrane L-kynurenine Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Regulation Of Cysteine Metabolic Process Regulation Of Glutathione Biosynthetic Process Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Glutamate Metabolic Process
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses	Basigin interactions Amino acid transport across the plasma membrane NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Cystine Glutamic acid Riluzole Sulfasalazine Acetylcysteine Thimerosal
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mood instability ( 31168069) Neurociticism ( 29500382) Sleep duration (> 10 hours) ( 33075057)
Interacting Genes		45 interacting genes: APOBEC3C BARD1 CASK CEBPA CNBP FLNA FOXP1 FTH1 GAR1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL HNRNPR LINC01554 MECOM NKAP OGT PABPC1 PAXIP1 PCBP1 PDIA3 PRPF40A PTBP1 PTBP2 QKI RALYL RBFOX2 RBMX RBPMS SF3B2 SLC7A11 SLU7 SNRPA SRSF3 SRSF7 SUMO2 UBC UTP25 WDR77 WDR83 YBX1 YBX2 YBX3	7 interacting genes: BAAT KRTAP1-1 KRTAP1-3 PCBP2 SLC3A2 TERT ZRANB1
Entrez ID		5094	23657
HPRD ID		03129	09720
Ensembl ID		ENSG00000197111	ENSG00000151012
Uniprot IDs		A0A384N6B9 Q15366	Q9UPY5
PDB IDs		2AXY 2JZX 2P2R 2PQU 2PY9	7CCS 7EPZ 7P9U 7P9V
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding MRNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Splicing MRNA Processing RNA Processing Nucleus Regulation Of MRNA Metabolic Process MRNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleoplasm RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II	Glycine N-choloyltransferase Activity Bile Acid Conjugation Apical Pole Of Neuron TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Medium-chain Fatty Acyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Exogenous Protein Binding Amino Acid Transport Complex Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Keratin Filament Methionine Transport L-leucine Import Across Plasma Membrane Aromatic Amino Acid Transmembrane Transporter Activity Tyrosine Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity L-histidine Transport Phenylalanine Transport Valine Transport L-alanine Import Across Plasma Membrane Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Isoleucine Transport L-leucine Transmembrane Transporter Activity L-alanine Transmembrane Transport Tryptophan Transport Protein K33-linked Deubiquitination Intermediate Filament Promoter-enhancer Loop Anchoring Activity L-alanine Transmembrane Transporter Activity Positive Regulation Of Protein Localization To Nucleolus Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral RNA Genome Replication Telomerase Activity Establishment Of Protein Localization To Telomere L-alanine Transport SiRNA Processing N-acyltransferase Activity Thiolester Hydrolase Activity L-leucine Transport Proline Transport Nuclear Telomere Cap Complex Taurine Metabolic Process
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