PCBP2 and HMGA2

Number of citations of the paper that reports this interaction (PubMedID 18850631)
0

Data Source:
BioGRID (pull down)

		PCBP2	HMGA2
Description		poly(rC) binding protein 2	high mobility group AT-hook 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Ribonucleoprotein Complex	Nuclear Chromosome Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding LncRNA Binding Promoter-enhancer Loop Anchoring Activity	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus IRES-dependent Viral Translational Initiation Chromatin Looping CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Cell Proliferation In Forebrain Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Chromosome Condensation Adrenal Gland Development Heterochromatin Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Multicellular Organism Growth Intracellular Signal Transduction Endodermal Cell Differentiation Chondrocyte Proliferation Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Regulation Of Growth Hormone Secretion Lung Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Stem Cell Proliferation Regulation Of Peptide Hormone Secretion Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adverse response to drug ( 30420678) Aortic root size ( 19584346) Appendicular lean mass ( 33097823) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 31043758 27680694 23202124) Body size at age 10 ( 32376654) Brain structure ( 22504417) Childhood body mass index ( 33045005) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 25282103 18391952 28552196 20881960 18391951 18391950 25429064 19343178 21998595 20397748 23563607 22021425 31562340 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Plateletcrit ( 32888494) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 31928498) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647 28869590 20581827 30297969 30054458 29358691 26961502 25102180 24509480 22885922) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		45 interacting genes: APOBEC3C BARD1 CASK CEBPA CNBP FLNA FOXP1 FTH1 GAR1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL HNRNPR LINC01554 MECOM NKAP OGT PABPC1 PAXIP1 PCBP1 PDIA3 PRPF40A PTBP1 PTBP2 QKI RALYL RBFOX2 RBMX RBPMS SF3B2 SLC7A11 SLU7 SNRPA SRSF3 SRSF7 SUMO2 UBC UTP25 WDR77 WDR83 YBX1 YBX2 YBX3	21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53
Entrez ID		5094	8091
HPRD ID		03129	02827
Ensembl ID		ENSG00000197111	ENSG00000149948
Uniprot IDs		A0A384N6B9 Q15366	F5H2A4 F5H6H0 P52926 Q1M183
PDB IDs		2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding MRNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Splicing MRNA Processing RNA Processing Nucleus Regulation Of MRNA Metabolic Process MRNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleoplasm RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process DNA Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Response To Stress Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Oxidative Stress
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