NR0B2 and CHRD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NR0B2	CHRD
Gene Name		nuclear receptor subfamily 0, group B, member 2	chordin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Extracellular Space
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding Heparin Binding Cytokine Binding Syndecan Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cholesterol Metabolic Process Response To Glucose Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Organ Regeneration Positive Regulation Of Insulin Secretion Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Platelet counts ( 20139978)
Protein-Protein Interactions		46 interactors: AR CHRD DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 IL3RA NCOA3 NR1H2 NR1H3 NR1I3 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 UBC VDR XBP1 ZAP70 ZMYND10	26 interactors: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NL NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1
Entrez ID		8431	8646
HPRD ID		05219	04592
Ensembl ID		ENSG00000131910	ENSG00000090539
Uniprot IDs		Q15466	E7ESX1 Q9H2X0
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus RNA Metabolic Process Response To Steroid Hormone Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process	Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Gene Expression Anterior/posterior Pattern Specification Positive Regulation Of Blood Coagulation Regulation Of Wound Healing Anatomical Structure Morphogenesis Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Sensory Organ Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Wound Healing Organ Morphogenesis System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Cell-matrix Adhesion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Inner Ear Development Embryo Development Platelet Activation Pattern Specification Process Embryonic Organ Development Ear Development Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cartilage Development Positive Regulation Of Cellular Metabolic Process Skeletal System Development Regulation Of Blood Coagulation Ossification Positive Regulation Of Metabolic Process Inner Ear Morphogenesis Wound Healing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Embryonic Organ Morphogenesis Regulation Of Cell-matrix Adhesion Embryonic Morphogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Proliferation
Tagcloud ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?