NR0B2 and NR1I3

Number of citations of the paper that reports this interaction (PubMedID 8650544)
0

Data Source:
HPRD (two hybrid, in vitro)

		NR0B2	NR1I3
Description		nuclear receptor subfamily 0 group B member 2	nuclear receptor subfamily 1 group I member 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear Receptor transcription pathway
Drugs			Doxylamine Meclizine Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)
Interacting Genes		51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10	18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC
Entrez ID		8431	9970
HPRD ID		05219	04858
Ensembl ID		ENSG00000131910	ENSG00000143257
Uniprot IDs		Q15466	F1DAL4 Q14994
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M 7YXC 7YXD 7YXN 7YXO 7YXP 7YXR	1XV9 1XVP
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Retinoic Acid Receptor Signaling Pathway Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process Cell Differentiation MRNA Transcription DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process	Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II Proteasome-activating Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus MRNA Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Regulation Of Vitamin D Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process General Transcription Initiation Factor Binding Proteasome Regulatory Particle, Base Subcomplex Progesterone Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Vitamin D Receptor Binding Proteasomal Protein Catabolic Process Rhythmic Process Proteasome Accessory Complex Nuclear Retinoid X Receptor Binding Positive Regulation Of Keratinocyte Differentiation Branching Involved In Mammary Gland Duct Morphogenesis Monocyte Differentiation Nucleoplasm
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