NR0B2 and RNF31

Number of citations of the paper that reports this interaction (PubMedID 19237537)
53

Data Source:
BioGRID (two hybrid)

		NR0B2	RNF31
Description		nuclear receptor subfamily 0 group B member 2	ring finger protein 31
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process	Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Ubiquitination CD40 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Xenophagy
Pathways		Nuclear Receptor transcription pathway	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)	Suicide behavior ( 26079190)
Interacting Genes		51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10	60 interacting genes: ACVRL1 AGO2 ATG13 ATN1 ATXN1 ATXN7 AZI2 CASP1 CASP6 CASP8 CCDC24 CDC34 GFI1B GPX4 HDAC6 IKBKG KIF1A KRTAP9-2 MECOM NOS3 NR0B1 NR0B2 PINK1 PITX1 PRKCA PTEN RBCK1 RNF26 SEPTIN2 SHARPIN SMAD3 SNRPC SOCS3 STAT3 STK4 TLE5 TNF TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1
Entrez ID		8431	55072
HPRD ID		05219	11516
Ensembl ID		ENSG00000131910	ENSG00000092098
Uniprot IDs		Q15466	Q96EP0
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M 7YXC 7YXD 7YXN 7YXO 7YXP 7YXR	2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9 7TV4 7UY2 7UYJ 7UYK 7V8F 7V8G 8Z30 8Z36 9AZJ 9B0B 9B0Z 9B12
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Retinoic Acid Receptor Signaling Pathway Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process Cell Differentiation MRNA Transcription DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Transferase Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process ATP Binding Nucleotide Binding Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Cytosol Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein-containing Complex Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication
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