NR0B2 and HDAC6

Number of citations of the paper that reports this interaction (PubMedID 15835920)
0

Data Source:
BioGRID (pull down)

		NR0B2	HDAC6
Description		nuclear receptor subfamily 0 group B member 2	histone deacetylase 6
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Centrosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Caveola Cilium Microtubule Cytoskeleton Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Protein-containing Complex Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection Axon Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Deacetylase Activity Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Protein Lysine Deacetylase Activity Peroxidase Inhibitor Activity ATPase Inhibitor Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Metal Ion Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process	Protein Polyubiquitination Response To Amphetamine Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Response To Stress Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Neuron Projection Development Macroautophagy Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Positive Regulation Of Protein Oligomerization Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Immobilization Stress Cellular Response To Topologically Incorrect Protein Aggrephagy Erythrocyte Enucleation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Collateral Sprouting Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Response To Corticosterone Mitochondrion Localization Response To Misfolded Protein Positive Regulation Of Synaptic Transmission, Glutamatergic Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Cilium Disassembly Type 2 Mitophagy Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Misfolded Protein Cellular Response To Parathyroid Hormone Stimulus Response To Dexamethasone Tubulin Deacetylation Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation Membraneless Organelle Assembly Positive Regulation Of Cellular Response To Oxidative Stress Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Aggrephagy
Pathways		Nuclear Receptor transcription pathway	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)
Interacting Genes		51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10	83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CRBN CSNK2A2 CYLD DSCR9 DYNLL2 EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H2AX H4C16 HDAC11 HES1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MOB1A MSH2 NACAD NASP NEDD8 NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF168 RNF31 RUNX2 SEPTIN7 SIRT2 SYK TEKT4 TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 ZBTB16 ZNF205
Entrez ID		8431	10013
HPRD ID		05219	02228
Ensembl ID		ENSG00000131910	ENSG00000094631
Uniprot IDs		Q15466	B4DZH6 Q9BRX7 Q9UBN7
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M 7YXC 7YXD 7YXN 7YXO 7YXP 7YXR	3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF 7ZYU 8G43 8G44 8G45
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Retinoic Acid Receptor Signaling Pathway Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process Cell Differentiation MRNA Transcription DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process	Nucleus Protein Modification Process Cytosol Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Protein-containing Complex Protein Modification By Small Protein Conjugation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Stress Microtubule Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Deacetylation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Nucleoplasm Protein Tag Activity Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly Glial Cell Differentiation Positive Regulation Of Developmental Process DNA Damage Response Cell Differentiation Cellular Response To Stress Developmental Process Regulation Of DNA-templated Transcription Regulation Of Signaling Regulation Of Cell Communication
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