NR0B2 and HDAC6

Number of citations of the paper that reports this interaction (PMID 15835920)
16

Data Source:
BioGRID (pull down)

		NR0B2	HDAC6
Gene Name		nuclear receptor subfamily 0, group B, member 2	histone deacetylase 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Core Promoter Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cholesterol Metabolic Process Response To Glucose Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Organ Regeneration Positive Regulation Of Insulin Secretion Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Polyubiquitination Transcription, DNA-templated Protein Deacetylation Misfolded Or Incompletely Synthesized Protein Catabolic Process Intracellular Protein Transport Organelle Organization Negative Regulation Of Microtubule Depolymerization Response To Toxic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Receptor Activity Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Macroautophagy Histone Deacetylation Lysosome Localization Cellular Response To Heat Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Complex Disassembly Negative Regulation Of Protein Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		46 interactors: AR CHRD DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 IL3RA NCOA3 NR1H2 NR1H3 NR1I3 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 UBC VDR XBP1 ZAP70 ZMYND10	67 interactors: ADRB2 ADRBK1 ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CORD1 CSNK2A2 CTNNB1 CTTN CYLD EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB G3BP1 HDAC11 HES1 HIST4H4 HSP90AA1 JDP2 KPNA1 LCOR LPXN MAPK3 NACAD NASP NR0B2 NR3C1 PKN1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PTOV1 PXN RELB RUNX2 SIRT2 SYK TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 ZBTB16 ZNF205
Entrez ID		8431	10013
HPRD ID		05219	02228
Ensembl ID		ENSG00000131910	ENSG00000094631
Uniprot IDs		Q15466	Q9UBN7
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR	3C5K 3GV4 3PHD
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus RNA Metabolic Process Response To Steroid Hormone Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process	Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process RNA Biosynthetic Process Protein Complex Assembly Positive Regulation Of Protein Modification Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Death Defense Response Regulation Of Nitrogen Compound Metabolic Process Death Positive Regulation Of Transferase Activity Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response Mitotic Cell Cycle
Tagcloud ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Difference) ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Intersection) ?