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TLE1 and IL6ST
Number of citations of the paper that reports this interaction (PubMedID
12030375
)
0
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(in vitro, in vivo, two hybrid)
TLE1
IL6ST
Description
TLE family member 1, transcriptional corepressor
interleukin 6 cytokine family signal transducer
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Beta-catenin-TCF Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Interleukin-6 Receptor Complex
Oncostatin-M Receptor Complex
External Side Of Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Cell Body
Membrane Raft
Extracellular Exosome
Ciliary Neurotrophic Factor Receptor Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Identical Protein Binding
DNA-binding Transcription Factor Binding
Cytokine Receptor Activity
Ciliary Neurotrophic Factor Receptor Activity
Interleukin-6 Receptor Activity
Interleukin-11 Receptor Activity
Leukemia Inhibitory Factor Receptor Activity
Oncostatin-M Receptor Activity
Ciliary Neurotrophic Factor Receptor Binding
Interleukin-6 Receptor Binding
Protein Binding
Coreceptor Activity
Growth Factor Binding
Cytokine Binding
Interleukin-11 Binding
Interleukin-6 Binding
Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Interleukin-27 Receptor Activity
Scaffold Protein Binding
Biological Process
Regulation Of DNA-templated Transcription
Signal Transduction
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Anoikis
Positive Regulation Of Acute Inflammatory Response
Positive Regulation Of Adaptive Immune Response
Glycogen Metabolic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Regulation Of Notch Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Cardiac Muscle Hypertrophy
Cytokine-mediated Signaling Pathway
Cell Differentiation
Response To Cytokine
Interleukin-11-mediated Signaling Pathway
Oncostatin-M-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Astrocyte Differentiation
Leukemia Inhibitory Factor Signaling Pathway
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Ciliary Neurotrophic Factor-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Platelet Aggregation
Pathways
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
Repression of WNT target genes
Negative Regulation of CDH1 Gene Transcription
Interleukin-6 signaling
Interleukin-6 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling
Interleukin-27 signaling
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Forehead morphology (
29921221
)
Hippocampal atrophy (
22745009
)
Lung adenocarcinoma (
28604730
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Moderate-to-late spontaneous preterm birth (
31194736
)
Rheumatoid arthritis (
30891314
)
Schizophrenia (
25056061
)
Type 2 diabetes (
22885922
32499647
30718926
30297969
30054458
28869590
26818947
24509480
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral fat (
22589738
)
Blood protein levels (
30072576
)
Crohn's disease (
23128233
)
IgG glycosylation (
23382691
)
Mean spheric corpuscular volume (
32888494
)
Type 1 diabetes (
34127860
)
Interacting Genes
83 interacting genes:
ANXA7
APH1A
ARL3
ARL4D
ATN1
BARHL1
BCL2L1
BID
BTBD2
CCL18
CDK1
CDKN1A
CDKN2C
CELF3
CRCT1
CSNK2B
CTNNB1
DAZAP2
DLEU1
EIF2S2
EN1
ERH
ESRRG
FOXA1
FOXA2
FOXA3
FOXG1
FUBP1
FXYD6
GADD45A
GRB7
GSK3B
GSTM4
HES1
HES6
HESX1
HHEX
HLA-DQA1
HMGB1
HNF1A
HSPE1
IL6ST
KDM6A
KIAA0408
LEF1
MORF4L2
MPHOSPH6
MSX1
MSX2
NKX2-5
NUDT21
PAFAH1B3
PAX9
PCDHA4
PEX2
PFN1
POLB
POLE2
PRDM1
PSMD11
RAP1B
RCC1
RNF10
RPA2
RUNX1
RUNX3
SAT1
SERPINB9
SIX1
SIX2
SIX3
SIX6
SMN1
SNRPG
TCF3
TCF4
TK1
TLE2
TLX1
TLX2
TSC22D1
UTY
ZFP64
35 interacting genes:
AR
CDK9
CMYA5
CNTF
CNTFR
CTF1
ERBB2
ERBB3
HCK
IL31RA
IL6
IL6R
JAK1
KCNIP1
KCNIP3
LIF
LIFR
MAGEA11
NEDD4L
OSM
OSMR
PIK3CG
PLAUR
PRKCD
PTPN11
PTPN6
SGTA
SGTB
SHC1
SOCS3
STAT3
TLE1
TYK2
UBQLN1
VAV1
Entrez ID
7088
3572
HPRD ID
02557
02824
Ensembl ID
ENSG00000196781
ENSG00000134352
Uniprot IDs
B4DEF9
Q04724
Q59EF7
A0A0A0N0L2
A0A0A0N0L5
A0A8V8TMJ9
A0A8V8TNI4
P40189
Q17RA0
PDB IDs
1GXR
2CE8
2CE9
4OM2
4OM3
5MWJ
1BJ8
1BQU
1I1R
1P9M
1PVH
3L5H
3L5I
3L5J
7U7N
8D6A
8D74
8D7R
8D82
8D85
8DPS
8DPT
8DPU
8UPA
8V29
8V2A
Enriched GO Terms of Interacting Partners
?
Sequence-specific Double-stranded DNA Binding
Chromatin
Developmental Process
Nucleus
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Cis-regulatory Region Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Animal Organ Development
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription Regulator Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Developmental Process
Sequence-specific DNA Binding
Pattern Specification Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Cell Differentiation
DNA-binding Transcription Factor Activity
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regionalization
Negative Regulation Of DNA-templated Transcription
Cellular Developmental Process
Negative Regulation Of RNA Biosynthetic Process
Cell Population Proliferation
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Differentiation
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Mesenchymal Cell Differentiation
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Developmental Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Positive Regulation Of Metabolic Process
Transcription Corepressor Binding
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphate Metabolic Process
T-helper 17 Cell Lineage Commitment
Regulation Of Cell Population Proliferation
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Signal Transduction
Interleukin-6-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
T-helper Cell Lineage Commitment
Negative Regulation Of Apoptotic Process
Interleukin-11-mediated Signaling Pathway
Phosphotyrosine Residue Binding
CD4-positive, Alpha-beta T Cell Lineage Commitment
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Alpha-beta T Cell Lineage Commitment
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Regulation Of Cell Adhesion
Regulation Of MAPK Cascade
Regulation Of Apoptotic Process
T Cell Lineage Commitment
Receptor Complex
Positive Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Ciliary Neurotrophic Factor Receptor Activity
Oncostatin-M-mediated Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Gene Expression
Regulation Of Cell-cell Adhesion
Regulation Of Defense Response
Regulation Of Macromolecule Metabolic Process
Cytokine Receptor Activity
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
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