TLE1 and FOXA1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TLE1	FOXA1
Gene Name		transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	forkhead box A1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol	Nucleus Nucleolus Microvillus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Protein Binding Transcription Factor Binding Identical Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Multicellular Organismal Development Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Anoikis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Transcription From RNA Polymerase II Promoter Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		85 interactors: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY VENTX ZFP64	5 interactors: AR HIST3H3 ONECUT1 SEZ6L2 TLE1
Entrez ID		7088	3169
HPRD ID		02557	03801
Ensembl ID		ENSG00000196781	ENSG00000129514
Uniprot IDs		Q04724	B7ZAP5 P55317
PDB IDs		1GXR 2CE8 2CE9
Enriched GO Terms of Interacting Partners?		System Development Nervous System Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Regulation Of Gene Expression Epithelium Development Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Tissue Development Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Organ Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Neurogenesis RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Generation Of Neurons Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Central Nervous System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Negative Regulation Of Integrin Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Regulation Of Integrin Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Anoikis Gland Development Nitrogen Compound Metabolic Process Regulation Of Anoikis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase III Promoter RNA Biosynthetic Process Regulation Of Signal Transduction Androgen Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Plasma Membrane Organ Development Spleen Development Regulation Of Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane RNA Metabolic Process Endocrine Pancreas Development Negative Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Telomere Maintenance Macromolecule Biosynthetic Process
Tagcloud ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	3a 3b advance brca1 chip deficent deoxycitydine deposit dnmt dnmt3b doi downregulation ezh2 familial gsk126 h3k27me3 hypermethylation impairs likewise maintains methylation methyltransferase methyltransferases mmecs notion onc publication reconstituted reconstitution
Tagcloud (Difference) ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	3a 3b advance brca1 chip deficent deoxycitydine deposit dnmt dnmt3b doi downregulation ezh2 familial gsk126 h3k27me3 hypermethylation impairs likewise maintains methylation methyltransferase methyltransferases mmecs notion onc publication reconstituted reconstitution
Tagcloud (Intersection) ?