TLE1 and ZFP64

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLE1	ZFP64
Gene Name		transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	ZFP64 zinc finger protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Protein Binding Transcription Factor Binding Identical Protein Binding	DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Multicellular Organismal Development Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Anoikis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Amyotrophic lateral sclerosis ( 17362836) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		85 interactors: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY VENTX ZFP64	21 interactors: AEN BARD1 BEGAIN BYSL C14orf1 FAM124A FHL2 LMO2 LNX1 MAFB MFAP1 MTUS2 PBK PPARGC1B SETDB1 TLE1 TRIM41 UNC119 ZBTB9 ZNF513 ZNF70
Entrez ID		7088	55734
HPRD ID		02557	15728
Ensembl ID		ENSG00000196781	ENSG00000020256
Uniprot IDs		Q04724	B3KQX0 Q9NPA5 Q9NTW7
PDB IDs		1GXR 2CE8 2CE9	1X5W 2DMD
Enriched GO Terms of Interacting Partners?		System Development Nervous System Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Regulation Of Gene Expression Epithelium Development Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Tissue Development Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Organ Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Neurogenesis RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Generation Of Neurons Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Central Nervous System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Transcription, DNA-templated Negative Regulation Of Erythrocyte Differentiation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Regulation Of Nitrogen Compound Metabolic Process Gene Expression Trabecula Morphogenesis Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Rhombomere 6 Development Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Biosynthetic Process Negative Regulation Of MRNA 3'-end Processing Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Gene Expression Negative Regulation Of Myeloid Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Brain Segmentation Atrial Cardiac Muscle Cell Development Cytokinesis, Completion Of Separation Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Blastocyst Development Metabolic Process Regulation Of Nucleic Acid-templated Transcription Rhombomere 5 Development Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Radiation Negative Regulation Of Protein Export From Nucleus Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Gene Expression Organ Development Mitotic Cytokinetic Process Protein K6-linked Ubiquitination Organ Morphogenesis Histone H3-K9 Trimethylation Visual Perception Sensory Perception Of Light Stimulus
Tagcloud ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	13q 17p 18q 22q 3p 4p 5q 9p dkk gastric heterozygosity hpp1 imc imcs instability intramucosal loh methylated methylations microsatellite mlh msi rassf2a runx3 sall4 sfrp1 smc smcs submucosal
Tagcloud (Difference) ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	13q 17p 18q 22q 3p 4p 5q 9p dkk gastric heterozygosity hpp1 imc imcs instability intramucosal loh methylated methylations microsatellite mlh msi rassf2a runx3 sall4 sfrp1 smc smcs submucosal
Tagcloud (Intersection) ?