TLE1 and SIX6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		TLE1	SIX6
Description		TLE family member 1, transcriptional corepressor	SIX homeobox 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Appendicular lean mass ( 33097823) Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 32499647 30718926 30297969 30054458 28869590 26818947 24509480) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 33627673 29891935 29452408 22570617 25173105) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 28073927 25631615 31798171) Optic disc area ( 25631615 28073927 31798171) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 28073927 31798171 25241763)
Interacting Genes		83 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TSC22D1 UTY ZFP64	3 interacting genes: GTF2A1L TLE1 TLE5
Entrez ID		7088	4990
HPRD ID		02557	07557
Ensembl ID		ENSG00000196781	ENSG00000184302
Uniprot IDs		B4DEF9 Q04724 Q59EF7	O95475 Q6P051
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Chromatin Developmental Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regionalization Negative Regulation Of DNA-templated Transcription Cellular Developmental Process Negative Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Mesenchymal Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Transcription Corepressor Binding	Regulation Of Anoikis Transcription Corepressor Activity Positive Regulation Of Anoikis Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Translation In Response To Stress Transcription Factor TFIIA Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Glial Cell Proliferation Regulation Of B Cell Receptor Signaling Pathway Translation Regulator Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Keratinocyte Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine Kinase Binding Beta-catenin-TCF Complex Negative Regulation Of Anoikis Regulation Of PERK-mediated Unfolded Protein Response Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation
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