PARN and KHSRP

Number of citations of the paper that reports this interaction (PMID 15175153)
125

Data Source:
HPRD (in vitro, in vivo)

		PARN	KHSRP
Gene Name		poly(A)-specific ribonuclease	KH-type splicing regulatory protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol	Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane
	Molecular Function	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding	DNA Binding MRNA Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing Gene Expression MRNA Transport Regulation Of MiRNA Metabolic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L	12 interactors: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 PARN PTBP2 STK3
Entrez ID		5073	8570
HPRD ID		07250	10350
Ensembl ID		ENSG00000140694	ENSG00000088247
Uniprot IDs		B3KN69 B4DSB0 O95453	Q92945
PDB IDs		2A1R 2A1S 3CTR	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization	MRNA Metabolic Process RNA Processing Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Localization Nitrogen Compound Metabolic Process MRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process SnoRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Maturation Of 5.8S RRNA Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process Gene Expression MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process SnRNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death SnRNA Metabolic Process Regulation Of Growth Positive Regulation Of Cell Death MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Positive Regulation Of Protein Binding Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Tagcloud ?		ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr	apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Difference) ?		ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr	apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Intersection) ?