PARN and SPATC1L

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		PARN	SPATC1L
Description		poly(A)-specific ribonuclease	spermatogenesis and centriole associated 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck Postsynapse Glutamatergic Synapse	Cytoplasm Centrosome Sperm Head-tail Coupling Apparatus
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	Protein Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA Sno(s)RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Telomerase RNA Stabilization LncRNA Processing Regulation Of Telomerase RNA Localization To Cajal Body PriRNA 3'-end Processing SiRNA 3'-end Processing	Spermatogenesis Actin Polymerization Or Depolymerization Positive Regulation Of CAMP/PKA Signal Transduction
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		8 interacting genes: FOXP1 KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2 UBC	51 interacting genes: ACOT7 ARL4A ARMC7 ATPAF2 CABP2 CLTC DISC1 EXOSC8 FOXN1 FSD2 GOLGA6A GTF3C6 HOOK2 IKZF1 KIFC3 KRT40 KRTAP5-9 LZTS2 MISP MTUS2 MYO15B NCK2 NUTF2 NXF1 PARN PHC2 PHF11 PIAS2 PICK1 PINK1 PLEC PNMA1 POLR1C PPP1CB PPP1CC QARS1 RAD51D RBMY1F RBMY1J REL SIAH1 SNRNP70 SYCE1 TCF4 TEKT4 TRIM27 TRMO TSR2 UBL5 ZBTB4 ZBTB8B
Entrez ID		5073	84221
HPRD ID		07250	10753
Ensembl ID		ENSG00000140694	ENSG00000160284
Uniprot IDs		A0A494C0Q2 A0A494C1K5 A0A494C1N1 B3KN69 O95453	Q9H0A9
PDB IDs		2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Exosome (RNase Complex)	Protein Binding Cytoskeleton Identical Protein Binding Nucleus RNA Metabolic Process PTW/PP1 Phosphatase Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing
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