PARN

Gene Name		poly(A)-specific ribonuclease
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L
Entrez ID		5073
HPRD ID		07250
Ensembl ID		ENSG00000140694
Uniprot IDs		B3KN69 B4DSB0 O95453
PDB IDs		2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization
Tagcloud ?		ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr