PARN

Description		poly(A)-specific ribonuclease
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck Postsynapse Glutamatergic Synapse
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA Sno(s)RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Telomerase RNA Stabilization LncRNA Processing Regulation Of Telomerase RNA Localization To Cajal Body PriRNA 3'-end Processing SiRNA 3'-end Processing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		8 interacting genes: FOXP1 KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2 UBC
Entrez ID		5073
HPRD ID		07250
Ensembl ID		ENSG00000140694
Uniprot IDs		A0A494C0Q2 A0A494C1K5 A0A494C1N1 B3KN69 O95453
PDB IDs		2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Exosome (RNase Complex)
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