ARHGAP22 and CCNDBP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ARHGAP22	CCNDBP1
Description		Rho GTPase activating protein 22	cyclin D1 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Femur bone mineral density x serum urate levels interaction ( 34046847) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		8 interacting genes: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA	114 interacting genes: ADGRA2 AMPD2 AQP1 ARHGAP22 ATP4B C22orf23 CCDC146 CCDC187 CCND1 CDK18 CDKN2A CFAP65 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM161A FAM74A4 FH FZD10 GAS2L2 GLIDR GRAP2 GSTK1 HBZ HDAC4 HMGB1 HSPB1 HYCC1 ILF2 IMP3 IRGC LIN37 LNX1 MAP2K2 MOS MRPL15 MRPS9 MTDH NAIF1 NANOS2 NEURL3 NOL7 NSMF NUDCD3 PAXIP1 PEX39 PIAS2 PIMREG PLEKHA7 PMP2 POLDIP3 POLL PRPF31 PSMB10 PTF1A RARA RARB RBP5 RPL28 RPL39L RPL7L1 RPS28 SASH1 SHFL SIRT6 SLC16A13 SPG7 STK25 SYF2 TCEAL1 TEAD4 TFPT THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS WNT11 ZBTB24 ZGPAT ZNF124 ZNF136 ZNF155 ZNF169 ZNF20 ZNF223 ZNF230 ZNF334 ZNF394 ZNF417 ZNF439 ZNF440 ZNF480 ZNF490 ZNF552 ZNF555 ZNF557 ZNF564 ZNF578 ZNF581 ZNF627 ZNF670 ZNF696 ZNF697 ZNF707 ZNF785 ZNF786 ZNF835 ZNF837 ZNRF2P1 ZSCAN26
Entrez ID		58504	23582
HPRD ID		12476	06156
Ensembl ID		ENSG00000128805	ENSG00000166946
Uniprot IDs		A0A2X0SFC0 Q7Z5H3	B4DHB5 O95273
PDB IDs			3AY5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity	Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Heterocyclic Compound Binding Regulation Of Metabolic Process SUMO Transferase Activity
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