ARHGAP22 and IL1RAPL1

Number of citations of the paper that reports this interaction (PubMedID 21926414)
36

Data Source:
BioGRID (pull down)

		ARHGAP22	IL1RAPL1
Description		Rho GTPase activating protein 22	interleukin 1 receptor accessory protein like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse	Cytoplasm Plasma Membrane Cell Surface Membrane Axon Dendrite Cell Projection Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding	Signaling Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization	Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Exocytosis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Regulation Of Postsynapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Receptor-type tyrosine-protein phosphatases Interleukin-38 signaling
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Femur bone mineral density x serum urate levels interaction ( 34046847) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)	Cardiovascular risk factors (age interaction) ( 20838585) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA	2 interacting genes: ARHGAP22 NCS1
Entrez ID		58504	11141
HPRD ID		12476	02193
Ensembl ID		ENSG00000128805	ENSG00000169306
Uniprot IDs		A0A2X0SFC0 Q7Z5H3	Q9NZN1 X5DNQ7
PDB IDs			1T3G 4M92 5WY8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity	Mitotic DNA Replication Initiation Lagging Strand Elongation Alpha DNA Polymerase:primase Complex DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Calcium Sensitive Guanylate Cyclase Activator Activity DNA Replication, Synthesis Of Primer DNA Strand Elongation Involved In DNA Replication DNA Polymerase Activity DNA Replication Origin Binding DNA Strand Elongation DNA-directed DNA Polymerase Activity DNA Replication Initiation Voltage-gated Calcium Channel Activity
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