SERPINB2 and IRF3

Number of citations of the paper that reports this interaction (PMID 12883638)
1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SERPINB2	IRF3
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 2	interferon regulatory factor 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Negative Regulation Of Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death
Pathways		Dissolution of Fibrin Clot	Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN
Drugs		Urokinase Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP IRF3 PLAU PRPF8 PSMB1 RB1	25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A
Entrez ID		5055	3661
HPRD ID		01420	04769
Ensembl ID		ENSG00000197632	ENSG00000126456
Uniprot IDs		P05120	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs		1BY7 1JRR 2ARQ 2ARR	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Neuron Maturation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Neuron Death Regulation Of Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signaling Viral Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Gene Expression Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Regulation Of Proteolysis Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Synaptic Growth At Neuromuscular Junction MDA-5 Signaling Pathway Macrophage Apoptotic Process Sister Chromatid Biorientation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Maturation Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Cell Cycle Checkpoint Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Centromere Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cohesin Localization To Chromatin	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Difference) ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Intersection) ?