SERPINB2 and PLAU

Number of citations of the paper that reports this interaction (PMID 2166055)
70

Data Source:
HPRD (in vitro, in vivo)

		SERPINB2	PLAU
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 2	plasminogen activator, urokinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Negative Regulation Of Apoptotic Process	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Blood Coagulation Regulation Of Receptor Activity Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Proliferation Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways		Dissolution of Fibrin Clot	Dissolution of Fibrin Clot
Drugs		Urokinase Tenecteplase	Urokinase Amiloride 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-5-Hydroxy-Benzimidazole N-(1-Adamantyl)-N\'-(4-Guanidinobenzyl)Urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N\'-Beta-Alanine 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP IRF3 PLAU PRPF8 PSMB1 RB1	24 interactors: ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINE2 SERPINF2 ST14
Entrez ID		5055	5328
HPRD ID		01420	01883
Ensembl ID		ENSG00000197632	ENSG00000122861
Uniprot IDs		P05120	P00749 Q59GZ8
PDB IDs		1BY7 1JRR 2ARQ 2ARR	1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4JK5 4JK6
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Neuron Maturation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Neuron Death Regulation Of Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signaling Viral Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Gene Expression Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Regulation Of Proteolysis Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Synaptic Growth At Neuromuscular Junction MDA-5 Signaling Pathway Macrophage Apoptotic Process Sister Chromatid Biorientation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Maturation Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Cell Cycle Checkpoint Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Centromere Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cohesin Localization To Chromatin	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Body Fluid Levels Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Plasminogen Activation Response To Stress Positive Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Coagulation Negative Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Secretion By Cell Platelet Degranulation Exocytosis Platelet Activation Extracellular Matrix Organization Extracellular Structure Organization Secretion Extracellular Matrix Disassembly Cell Activation Multicellular Organismal Development Developmental Process System Development Negative Regulation Of Catalytic Activity Anatomical Structure Development Response To Stimulus Positive Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?