SERPINB2 and PRPF8

Number of citations of the paper that reports this interaction (PMID 15346200)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		SERPINB2	PRPF8
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 2	pre-mRNA processing factor 8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Binding U6 SnRNA Binding U5 SnRNA Binding Poly(A) RNA Binding K63-linked Polyubiquitin Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Negative Regulation Of Apoptotic Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression
Pathways		Dissolution of Fibrin Clot	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs		Urokinase Tenecteplase
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		6 interactors: APP IRF3 PLAU PRPF8 PSMB1 RB1	14 interactors: ABCA1 DHX9 EFTUD2 ERG GPKOW HNRNPH2 NEDD4 PIN1 PRPF19 SERPINB2 SND1 SNRNP200 UBC ZNF830
Entrez ID		5055	10594
HPRD ID		01420	06295
Ensembl ID		ENSG00000197632	ENSG00000174231
Uniprot IDs		P05120	Q6P2Q9
PDB IDs		1BY7 1JRR 2ARQ 2ARR	3E9L 3ENB 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Neuron Maturation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Neuron Death Regulation Of Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signaling Viral Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Gene Expression Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Regulation Of Proteolysis Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Synaptic Growth At Neuromuscular Junction MDA-5 Signaling Pathway Macrophage Apoptotic Process Sister Chromatid Biorientation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Maturation Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Cell Cycle Checkpoint Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Centromere Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cohesin Localization To Chromatin	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Osteoblast Differentiation DNA Damage Checkpoint Blastocyst Growth Protein Polyubiquitination RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Response To Stress Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Type I Interferon Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ossification Cellular Nitrogen Compound Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Potassium Ion Transport Spliceosomal Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Potassium Ion Export Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Heart Rate By Hormone Cellular Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Ion Transport Regulation Of Mitotic Cell Cycle
Tagcloud ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		4a africans aorta arteries asians atherosclerotic cerebral clip compares hepatocyte hispanics hnf4a hypercholesterolemia hypercholesterolemic hypertensive iclad ingenuity intracranial mca message mmp1 nfkb nodal rabbits stenosis ubc verified vessels zealand	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
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