PEBP1 and MAP3K14

Number of citations of the paper that reports this interaction (PubMedID 11585904)
79

Data Source:
HPRD (in vivo)

		PEBP1	MAP3K14
Description		phosphatidylethanolamine binding protein 1	mitogen-activated protein kinase kinase kinase 14
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Lipid Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding Peptidase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of MAPK Cascade	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31361310 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)
Interacting Genes		25 interacting genes: BRAF CACHD1 CEBPA CHUK DNMT1 ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2	42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91
Entrez ID		5037	9020
HPRD ID		06850	05230
Ensembl ID		ENSG00000089220	ENSG00000006062
Uniprot IDs		D9IAI1 P30086	Q99558
PDB IDs		1BD9 1BEH 2L7W 2QYQ	4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Signaling Cassette ATP Binding Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Response To Stress Response To Hormone Regulation Of Intracellular Signal Transduction Protein Kinase C Signaling Regulation Of MAPK Cascade Schwann Cell Development Response To Tumor Necrosis Factor Regulation Of Multicellular Organismal Process Face Development Regulation Of Cell Communication Regulation Of Signaling MAPK Cascade MAP Kinase Kinase Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Glial Cell Development ERBB2 Signaling Pathway Regulation Of Biological Quality Immune Response-activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding ERBB Signaling Pathway Thyroid Gland Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Developmental Process	Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction
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