PEBP1 and CACHD1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PEBP1	CACHD1
Description		phosphatidylethanolamine binding protein 1	cache domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Voltage-gated Calcium Channel Complex Membrane
	Molecular Function	Nucleotide Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Lipid Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding Peptidase Inhibitor Activity	Voltage-gated Calcium Channel Activity
	Biological Process	Negative Regulation Of MAPK Cascade	Monoatomic Ion Transport Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways		MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)	Gut microbiota relative abundance (Bifidobacterium) ( 33208821)
Interacting Genes		25 interacting genes: BRAF CACHD1 CEBPA CHUK DNMT1 ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2	6 interacting genes: BICRAL DYRK1A PEBP1 RANBP10 XAB2 ZMIZ1
Entrez ID		5037	57685
HPRD ID		06850	13874
Ensembl ID		ENSG00000089220	ENSG00000158966
Uniprot IDs		D9IAI1 P30086	A0A0A0MQY7 Q5VU97
PDB IDs		1BD9 1BEH 2L7W 2QYQ
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Signaling Cassette ATP Binding Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Response To Stress Response To Hormone Regulation Of Intracellular Signal Transduction Protein Kinase C Signaling Regulation Of MAPK Cascade Schwann Cell Development Response To Tumor Necrosis Factor Regulation Of Multicellular Organismal Process Face Development Regulation Of Cell Communication Regulation Of Signaling MAPK Cascade MAP Kinase Kinase Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Glial Cell Development ERBB2 Signaling Pathway Regulation Of Biological Quality Immune Response-activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding ERBB Signaling Pathway Thyroid Gland Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Developmental Process
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