PEBP1 and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 18816836)
45

Data Source:
BioGRID (two hybrid)

		PEBP1	NKX3-1
Description		phosphatidylethanolamine binding protein 1	NK3 homeobox 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	Nucleotide Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Lipid Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding Peptidase Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Prostate Gland Development Regulation Of Protein Localization Response To Testosterone Response To Lipid Dorsal Aorta Development Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		Copper
Diseases			Prostate cancer
GWAS		Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449 32986714 34012061) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: BRAF CACHD1 CEBPA CHUK DNMT1 ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2	38 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MRE11 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC67A1 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		5037	4824
HPRD ID		06850	03620
Ensembl ID		ENSG00000089220	ENSG00000167034
Uniprot IDs		D9IAI1 P30086	Q99801
PDB IDs		1BD9 1BEH 2L7W 2QYQ	2L9R
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Signaling Cassette ATP Binding Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Response To Stress Response To Hormone Regulation Of Intracellular Signal Transduction Protein Kinase C Signaling Regulation Of MAPK Cascade Schwann Cell Development Response To Tumor Necrosis Factor Regulation Of Multicellular Organismal Process Face Development Regulation Of Cell Communication Regulation Of Signaling MAPK Cascade MAP Kinase Kinase Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Glial Cell Development ERBB2 Signaling Pathway Regulation Of Biological Quality Immune Response-activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding ERBB Signaling Pathway Thyroid Gland Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Developmental Process	Nucleus DNA Binding PML Body Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Trachea Cartilage Development Sequence-specific Double-stranded DNA Binding Embryonic Eye Morphogenesis Glandular Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Double-stranded DNA Binding Regulation Of Programmed Cell Death DNA Damage Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Eye Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sensory Organ Morphogenesis Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Morphogenesis Zinc Ion Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Trophectodermal Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Face Development Regulation Of Macromolecule Biosynthetic Process Prostate Gland Epithelium Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To Stress Replication Fork Positive Regulation Of Macromolecule Metabolic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Thyroid Gland Development
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