SLC67A1 and HSD17B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC67A1	HSD17B11
Description		solute carrier family 67 member 1	hydroxysteroid 17-beta dehydrogenase 11
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Xenobiotic Transmembrane Transporter Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Organic Cation Transport Xenobiotic Transport Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		SLC-mediated transport of organic cations Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS			Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		5 interacting genes: HSD17B11 NKX3-1 RNF167 TLCD4 TMX2	54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6
Entrez ID		5002	51170
HPRD ID		04024	10881
Ensembl ID		ENSG00000110628	ENSG00000198189
Uniprot IDs		A0A024RCG2 E9PRM7 Q96BI1	Q8NBQ5
PDB IDs			1YB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Androgen Secretion MADS Box Domain Binding Ribonucleoside-diphosphate Reductase Activity Male Gonad Development Positive Regulation Of Mitotic Cell Cycle Gonad Development Dorsal Aorta Development Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Steroid Dehydrogenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Salivary Gland Development Reproductive Structure Development Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Androgen Catabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity
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