SLC22A18 and RNF167

Number of citations of the paper that reports this interaction (PMID 16314844)
5

Data Source:
BioGRID (enzymatic study)

		SLC22A18	RNF167
Gene Name		solute carrier family 22, member 18	ring finger protein 167
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane	Cytoplasm Endomembrane System Integral Component Of Membrane
	Molecular Function	Drug Transmembrane Transporter Activity Symporter Activity Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Drug Transmembrane Transport Excretion Organic Cation Transport Drug Transport Transmembrane Transport	Protein Polyubiquitination Negative Regulation Of Cell Cycle
Pathways		Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Calcium levels ( 20705733)
Protein-Protein Interactions		2 interactors: RNF167 UBC	11 interactors: SLC22A18 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2K UBE2N UBE2W
Entrez ID		5002	26001
HPRD ID		04024	15261
Ensembl ID		ENSG00000110628	ENSG00000108523
Uniprot IDs		Q96BI1	I3L0L6 Q9H6Y7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Negative Regulation Of Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Viral Protein Processing Regulation Of Cell Cycle Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Proteolysis Regulation Of Innate Immune Response Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Catabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Protein Monoubiquitination Cellular Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			abrogated abrogates attachment cargo cg10277 depend endocytosis endosome endosomes enlarged ethylmaleimide exocytosis giant godzilla goliath homologue ligases lysines lysosome rab5 recycled recycling snare sorting trafficking transcriptionally ubiquitylation vamp3 vesicle
Tagcloud (Difference) ?			abrogated abrogates attachment cargo cg10277 depend endocytosis endosome endosomes enlarged ethylmaleimide exocytosis giant godzilla goliath homologue ligases lysines lysosome rab5 recycled recycling snare sorting trafficking transcriptionally ubiquitylation vamp3 vesicle
Tagcloud (Intersection) ?