SLC67A1 and RRM1

		SLC67A1	RRM1
Description		solute carrier family 67 member 1	ribonucleotide reductase catalytic subunit M1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body
	Molecular Function	Protein Binding Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Xenobiotic Transmembrane Transporter Activity	Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Organic Cation Transport Xenobiotic Transport Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		SLC-mediated transport of organic cations Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS			Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		5 interacting genes: HSD17B11 NKX3-1 RNF167 TLCD4 TMX2	11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655
Entrez ID		5002	6240
HPRD ID		04024	01588
Ensembl ID		ENSG00000110628	ENSG00000167325
Uniprot IDs		A0A024RCG2 E9PRM7 Q96BI1	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs			2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Androgen Secretion MADS Box Domain Binding Ribonucleoside-diphosphate Reductase Activity Male Gonad Development Positive Regulation Of Mitotic Cell Cycle Gonad Development Dorsal Aorta Development Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Steroid Dehydrogenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Salivary Gland Development Reproductive Structure Development Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Androgen Catabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex
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