NUCB1 and GNAI3

Number of citations of the paper that reports this interaction (PMID 9647645)
28

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NUCB1	GNAI3
Gene Name		nucleobindin 1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Calcium Ion Binding Protein Binding	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process		Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division
Pathways			GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Major depressive disorder ( 20125088)
Protein-Protein Interactions		15 interactors: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PTGS1 PTGS2 RBL1 REL SET XPO1	40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		4924	2773
HPRD ID		03205	00765
Ensembl ID		ENSG00000104805
Uniprot IDs		A8K7Q1 Q02818	P08754 Q5TZX1
PDB IDs		1SNL	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Response To Organic Substance Platelet Activation Regulation Of Adenylate Cyclase Activity Cell Cycle Regulation Of Cyclase Activity Response To Drug Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Cyclooxygenase Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Response To Stimulus Response To Stress Signaling Prostaglandin Biosynthetic Process Cell Communication Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Lyase Activity Blood Coagulation Hemostasis Prostaglandin Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Regulation Of Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Genetic Imprinting Regulation Of Calcium Ion Transport Response To Transforming Growth Factor Beta Negative Regulation Of Nucleotide Metabolic Process Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion
Tagcloud ?			akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Difference) ?			akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Intersection) ?