NUCB1 and RBL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NUCB1	RBL1
Description		nucleobindin 1	RB transcriptional corepressor like 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Small GTPase-mediated Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 28957414 32888494)
Interacting Genes		18 interacting genes: DYRK1A GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1	55 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB1 PLSCR1 PPP1R9B PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		4924	5933
HPRD ID		03205	00312
Ensembl ID		ENSG00000104805	ENSG00000080839
Uniprot IDs		A8K7Q1 Q02818	P28749
PDB IDs		1SNL	1H28 4YOO 4YOS 4YOZ 5TUV 7SMC 7SMD 7SME 7SMF
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTP Binding Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion G Protein Activity Negative Regulation Of Protein Secretion Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Negative Regulation Of Transport Dioxygenase Activity Regulation Of Protein Transport Cell Body Negative Regulation Of Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Interferon-beta Production Prostaglandin Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Regulation Of Protein Secretion Prostanoid Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process G Protein-coupled Dopamine Receptor Signaling Pathway Protein-DNA Complex Disassembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Transport Regulation Of Secretion By Cell Response To Prostaglandin E	Nucleoplasm Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Cellular Response To Stress Mitotic Cell Cycle Phase Transition Response To Stress Cell Cycle Phase Transition Response To Growth Factor Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Binding
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