NUCB1 and PTGS1

Number of citations of the paper that reports this interaction (PubMedID 8643612)
32

Data Source:
HPRD (in vitro, two hybrid)

		NUCB1	PTGS1
Description		nucleobindin 1	prostaglandin-endoperoxide synthase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System Membrane Extracellular Exosome	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuron Projection Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Small GTPase-mediated Signal Transduction	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Population Proliferation Cellular Oxidant Detoxification
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin (+)-2-(4-biphenyl)propionic acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Nitroaspirin Bufexamac Bendazac Acemetacin Medical Cannabis Nabiximols
Diseases
GWAS			Glomerular filtration rate in chronic kidney disease ( 26420894) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		18 interacting genes: DYRK1A GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1	3 interacting genes: NCL NUCB1 PTGIS
Entrez ID		4924	5742
HPRD ID		03205	07518
Ensembl ID		ENSG00000104805	ENSG00000095303
Uniprot IDs		A8K7Q1 Q02818	A0A087X296 P23219
PDB IDs		1SNL	6Y3C
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTP Binding Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion G Protein Activity Negative Regulation Of Protein Secretion Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Negative Regulation Of Transport Dioxygenase Activity Regulation Of Protein Transport Cell Body Negative Regulation Of Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Interferon-beta Production Prostaglandin Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Regulation Of Protein Secretion Prostanoid Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process G Protein-coupled Dopamine Receptor Signaling Pathway Protein-DNA Complex Disassembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Transport Regulation Of Secretion By Cell Response To Prostaglandin E	Macropinosome Membrane Telomeric DNA Binding MRNA 5'-UTR Binding Response To Peptide Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I PH Domain Binding Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of MRNA Splicing, Via Spliceosome Response To Cytokine Cellular Response To Cytokine Stimulus Insulin Receptor Substrate Binding DNA Topoisomerase Binding G-protein Alpha-subunit Binding Positive Regulation Of Execution Phase Of Apoptosis Decidualization Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Purine-containing Compound Salvage Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway NAD+ Biosynthetic Process Response To Interleukin-6 Prostaglandin-I Synthase Activity Pyridine Nucleotide Biosynthetic Process Hydroperoxy Icosatetraenoate Dehydratase Activity NAD+ Biosynthetic Process Via The Salvage Pathway Purine Nucleotide Salvage Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Prostanoid Metabolic Process Positive Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase I NAD+ Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Cellular Response To Insulin Stimulus Response To Epidermal Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Interleukin-1 Cornified Envelope Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Regulation Of Nitric Oxide Biosynthetic Process Monooxygenase Activity Regulation Of Nitric Oxide Metabolic Process
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